Fludarabine, cyclophosphamide, anti‐thymocyteglobulin, and low‐dose total body irradiation conditioning enables 1‐HLA‐locus‐mismatched hematopoietic stem cell transplantation for very severe aplastic anemia without affecting ovarian function

作者：Shinya Okuda, Kiriko Terasako, Kumi Oshima, Miki Sato, Hideki Nakasone, Shinichi Kako, Rie Yamazaki, Yukië Tanaka, Aki Tanihara, Takakazu Higuchi, Junji Nishida, Yoshinobu Kanda · 发表于：American Journal of Hematology · 年份：2008 · DOI：10.1002/ajh.21355 · 被引用次数：18 · 研究领域：Hematopoietic Stem Cell Transplantation、Reproductive Biology and Fertility、Pluripotent Stem Cells Research

Allogeneic hematopoietic stem cell transplantation for severe aplastic anemia from an alternative donor is associated with higher risks of graft rejection and severe graft-versus-host disease. We developed a conditioning regimen consisting of rabbit anti-thymocyte globulin, fludarabine, cyclophosphamide, and low-dose total body irradiation. Two adult female patients with transfusion-dependent very severe aplastic anemia underwent 1-locus mismatched transplantation using this regimen. Both patients achieved stable engraftment and the clinical course thereafter was uneventful with persistently normal ovarian function. This novel conditioning regimen may be suitable for alternative donor transplantation for severe aplastic anemia, especially in young female patients.