Urinary 3-Methoxy-4-Hydroxyphenylglycol Circadian Rhythm

作者：Thomas A. Wehr · 发表于：Archives of General Psychiatry · 年份：1980 · DOI：10.1001/archpsyc.1980.01780160027002 · 被引用次数：195 · 研究领域：Mental Health Research Topics、Circadian rhythm and melatonin、Neurotransmitter Receptor Influence on Behavior

Twenty-four-hour (circadian) rhythms in urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) excretion, motor activity, and oral temperature were studied in 14 normal subjects and ten manic-depressive patients. In both groups, a daily rhythm in MHPG excretion was present, with daytime peaks and nighttime lows. This pattern of urinary MHPG excretion may reflect a rhythm in central noradrenergic function. The physiological changes in levels of MHPG excretion associated with the circadian rhythm were at least as great as pathological changes associated with manic-depressive illness. Compared with controls, the timing or phase of circadian rhythms in each variable was one to three hours earlier in the patients, whether depressed or manic. Although the presence of circadian rhythms complicates the task of designing clinical research procedures, their early timing in manic-depressives suggests that disturbances in central biological clocks may be an integral part of the pathophysiology of affective illness and may be related to disturbances of sleep and neuroendocrine function associated with depression.