Endothelial Cells and the Biology of Factor VIII

作者：Howard L. Bleich, Emily S. Boro, ERIC A. JAFFE · 发表于：New England Journal of Medicine · 年份：1977 · DOI：10.1056/nejm197702172960707 · 被引用次数：253 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Hemophilia Treatment and Research、Blood properties and coagulation

Endothelial cells line the insides of arteries, veins, capillaries and lymphatics, usually in a layer one cell thick. These cells have important roles in physiologic hemostasis, in the permeability of blood vessels and in mediation of their response to a variety of physiologic and pathologic stimuli.1 Abnormalities in the structure and function of endothelial cells may contribute substantially to diseases of blood-vessel walls, particularly thrombosis and atherosclerosis.1 2 3 To study the role of endothelial cells in these and other important biologic phenomena, my colleagues and I developed methods for identification and long-term culture of human endothelial cells.1 At about the same . . .