Activation of the Myogenic Lineage by MEF2A, a Factor that Induces and Cooperates with MyoD

作者：Sunjay Kaushal, Jay W. Schneider, Bernardo Nadal‐Ginard, Vijak Mahdavi · 发表于：Science · 年份：1994 · DOI：10.1126/science.7973707 · 被引用次数：237 · 研究领域：Muscle Physiology and Disorders、Genetics and Neurodevelopmental Disorders、Genomics and Chromatin Dynamics

Muscle enhancer factor-2A (MEF2A), a member of the MADS family, induced myogenic development when ectopically expressed in clones of nonmuscle cells of human clones, a function previously limited to the muscle basic helix-loop-helix (bHLH) proteins. During myogenesis, MEF2A and bHLH proteins cooperatively activate skeletal muscle genes and physically interact through the MADS domain of MEF2A and the three myogenic amino acids of the muscle bHLH proteins. Thus, skeletal myogenesis is mediated by two distinct families of mutually inducible and interactive muscle transcription factors, either of which can initiate the developmental cascade.