6,7-Dimethoxy- N -[3-(trifluoromethyl)phenyl]quinazolin-4-amine ethanol disolvate
作者:Min Xia · 发表于:Acta Crystallographica Section E Structure Reports Online · 年份:2005 · DOI:10.1107/s1600536805029521 · 被引用次数:2 · 研究领域:Quinazolinone synthesis and applications、Synthesis and Characterization of Heterocyclic Compounds、Microwave-Assisted Synthesis and Applications
The title compound, C17H14F3N3O2·2C2H5OH, was synthesized by the reaction of 4-chloro-6,7-dimethoxyquinazoline and 3-(trifluromethyl)aniline at 580 W in a domestic microwave oven and obtained in 93% yield. The bond lengths and angles are normal. Intermolecular N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds and π–π stacking interactions between the quinazoline rings of neighbouring molecules stabilize the crystal packing.