Metabolism of Propachlor by the Germfree Rat

作者：J. E. Bakke, Jan-Ακε Gustafsson, Bengt E. Gustafsson · 发表于：Science · 年份：1980 · DOI：10.1126/science.7433983 · 被引用次数：51 · 研究领域：Antibiotics Pharmacokinetics and Efficacy、Plant Toxicity and Pharmacological Properties、Drug-Induced Hepatotoxicity and Protection

Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.