Bacteriotherapy with Lactobacillus reuteri in rotavirus gastroenteritis

作者：Aino‐Vieno Shornikova, Ivàn A. Casas, Hannu M Mykkänen, Eeva Salo, Timo Vesikari · 发表于：The Pediatric Infectious Disease Journal · 年份：1997 · DOI：10.1097/00006454-199712000-00002 · 被引用次数：321 · 研究领域：Probiotics and Fermented Foods、Viral gastroenteritis research and epidemiology、Infant Nutrition and Health

BACKGROUND: Certain lactic acid bacteria may accelerate recovery from acute diarrhea. Lactobacillus reuteri is a commonly occurring Lactobacillus species with therapeutic potential in diarrhea. DESIGN: Prospective, randomized, placebo-controlled trial in two hospitals. METHODS: Children between 6 and 36 months of age admitted for rotavirus-associated diarrhea were randomized into three groups to receive either 10(10) or 10(7) colony-forming units (cfu) of L. reuteri or a matching placebo once a day for up to 5 days. RESULTS: The main effect of L. reuteri was on the duration of watery diarrhea. The mean (+/-SD) duration of watery diarrhea after initiation of treatment was 2.5 (1.5) days in the placebo group (n = 25) vs. 1.9 (0.9) days in the small dosage (n = 20) and 1.5 (1.1) days in the large dosage (n = 21) L. reuteri recipients (P = 0.01). By the second day of treatment watery diarrhea persisted in 80% of the placebo, 70% of the small dosage and 48% of the large dosage L. reuteri recipients (P = 0.04, large dosage vs. placebo). Stool cultures for lactobacilli confirmed that administration of L. reuteri resulted in good colonization of the GI tract. The mean (+/-SD) of total Lactobacillus count 2 days after treatment initiation was 2.8 (1.6) log 10 cfu/g in the placebo group, 4.5 (2.0) log 10 cfu/g in the small dosage L. reuteri group and 6.1 (1.2) log 10 cfu/g in the large dosage L. reuteri group (P = 0.0004). CONCLUSIONS: L. reuteri effectively colonized the gastrointesti...