Structure and function of the platelet integrin IIb 3

作者：JOEL S. BENNETT · 发表于：Journal of Clinical Investigation · 年份：2005 · DOI：10.1172/jci26989 · 被引用次数：357 · 研究领域：Cell Adhesion Molecules Research、Platelet Disorders and Treatments、Monoclonal and Polyclonal Antibodies Research

The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.