Lewy bodies in tyrosine hydroxylase-synthesizing neurons of the human cerebral cortex

作者：Rodrigo O. Kuljiš, Pablo Martı́n-Vasallo, Nancy S. Peress · 发表于：Neuroscience Letters · 年份：1989 · DOI：10.1016/0304-3940(89)90200-0 · 被引用次数：42 · 研究领域：Neurological disorders and treatments、Parkinson's Disease Mechanisms and Treatments、Genetic Neurodegenerative Diseases

A population of neurons situated in the human cerebral neocortex contains mRNA coding for tyrosine hydroxylase, the key enzyme for catecholamine biosynthesis. Phosphorylated neurofilament-containing cytoplasmic inclusions occur in these neurons in diffuse Lewy body disease, indicating a tendency for selective involvement that is shared with subcortical catecholamine-containing neurons. These findings are relevant to the pathophysiology of several neurologic and psychiatric illnesses in which the monoamine-containing neurons of the neocortex may participate.