Absence of Pneumocystis jirovecii dihydropteroate synthase gene mutations among samples from a group of AIDS patients in China

作者：Kai Li, Ai He, Wei Cai, Xiao Ping Tang, Xiaoying Zheng, Zhuo Ya Li, Xi Mei Zhan · 发表于：Scandinavian Journal of Infectious Diseases · 年份：2008 · DOI：10.1080/00365540802613087 · 被引用次数：14 · 研究领域：Pneumocystis jirovecii pneumonia detection and treatment、HIV/AIDS drug development and treatment、Tuberculosis Research and Epidemiology

Pneumocystis jirovecii dihydropteroate synthase (DHPS) gene mutations are associated with failure of sulfur prophylaxis of Pneumocystis pneumonia. Here the P. jirovecii DHPS gene was amplified from bronchoalveolar fluid of 10 AIDS patients in China. No DHPS gene mutations were observed. The results suggest that the prevalence of DHPS mutations in China may be low.