m-Hydroxyphenylacetic Acid Formation from L-Dopa in Man: Suppression by Neomycin

作者：Mark B. Sandler, Farouk Karoum, Colin R.J. Ruthven, Donald B. Calne · 发表于：Science · 年份：1969 · DOI：10.1126/science.166.3911.1417 · 被引用次数：56 · 研究领域：Diet and metabolism studies、Parkinson's Disease Mechanisms and Treatments、Ginger and Zingiberaceae research

The increased excretion of m-hydroxyphenylacetic acid in the urine of patients with parkinsonism being treated with L-dopa was reduced by gut sterilization with neomycin. The p-de-hydroxylation step is thus brought about solely by the action of gut flora; the pathway is unlikely to be involved in the events within the brain leading to the therapeutic benefit effected by L-dopa.