Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography

作者：Richard S. J. Frackowiak, Gian-Luigi Lenzi, Terry Jones, Jon D. Heather · 发表于：Journal of Computer Assisted Tomography · 年份：1980 · DOI：10.1097/00004728-198012000-00001 · 被引用次数：1246 · 研究领域：Traumatic Brain Injury and Neurovascular Disturbances、Medical Imaging Techniques and Applications、Optical Imaging and Spectroscopy Techniques

A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man non-invasively, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.