Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

作者：Gioacchino Natoli, Antonio Costanzo, Angelo Ianni, Dennis J. Templeton, James Robert Woodgett, Clara Balsano, Massimo Levrero · 发表于：Science · 年份：1997 · DOI：10.1126/science.275.5297.200 · 被引用次数：459 · 研究领域：NF-κB Signaling Pathways、Cell death mechanisms and regulation、interferon and immune responses

Interaction of the p55 tumor necrosis factor receptor 1 (TNF-R1)-associated signal transducer TRADD with FADD signals apoptosis, whereas the TNF receptor-associated factor 2 protein (TRAF2) is required for activation of the nuclear transcription factor nuclear factor kappa B. TNF-induced activation of the stress-activated protein kinase (SAPK) was shown to occur through a noncytotoxic TRAF2-dependent pathway. TRAF2 was both sufficient and necessary for activation of SAPK by TNF-R1; conversely, expression of a dominant-negative FADD mutant, which blocks apoptosis, did not interfere with SAPK activation. Therefore, SAPK activation occurs through a pathway that is not required for TNF-R1-induced apoptosis.