Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.

作者：Ludvig Magne Sollid, Gunnar Markussen, J. Ek, Hallvard Gjerde, Frode Vartdal, Erik Thorsby · 发表于：The Journal of Experimental Medicine · 年份：1989 · DOI：10.1084/jem.169.1.345 · 被引用次数：943 · 研究领域：Diabetes and associated disorders、Celiac Disease Research and Management、Digestive system and related health

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.