CHEMICAL ANALYSIS OF A SALIVARY GLYCOPROTEIN WITH BLOOD‐GROUP SUBSTANCE‐AND VIRUS INHIBITION ACTIVITIES

作者：Torleif Sönju, Gunnar Rölla · 发表于：Acta Pathologica Microbiologica Scandinavica Section B Microbiology and Immunology · 年份：1971 · DOI：10.1111/j.1699-0463.1971.tb00038.x · 被引用次数：19 · 研究领域：Influenza Virus Research Studies、Immune Response and Inflammation、Protein purification and stability

A human salivary glycoprotein which exhibits blood‐group substance activity in the ABO and Lewis systems, and which also inhibits the haemagglutinins of influenza virus (Rølla &Jonsen 1968) has been analysed. Glycoprotein preparations from a non‐secretor (O, Le a+b‐) and from a secretor (O, Le a‐b+) showed very similar amino acid composition, indicating identical protein cores in the two glycoproteins, whereas the secretor preparation contained more amino sugars and fucose. The salivary blood‐group active glycoproteins had an amino acid composition different from the ovarian cyst blood‐group substances and contained more protein than these preparations.