Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase Inhibitor

作者：D. Dvornik, Nicole Simard-Duquesne, M. Krami, Kazimir Sestanj, Kenneth H. Gabbay, J. H. Kinoshita, S.D. Varma, LORENZO O. MEROLA · 发表于：Science · 年份：1973 · 被引用次数：267 · 研究领域：Aldose Reductase and Taurine、Biochemical effects in animals、Cannabis and Cannabinoid Research

An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose. When given orally, AY-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactosemic rats with AY-22,284 effectively suppressed the formation of cataracts.