Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody

作者：Sarah Clarkson, James Bruce Bussel, Robert P. Kimberly, Jay E. Valinsky, Ralph L. Nachman, Jay C. Unkeless · 发表于：New England Journal of Medicine · 年份：1986 · DOI：10.1056/nejm198605083141907 · 被引用次数：367 · 研究领域：Platelet Disorders and Treatments、Monoclonal and Polyclonal Antibodies Research、Blood groups and transfusion

THE production of antiplatelet antibodies and removal of IgG-coated platelets by the mononuclear phagocyte system play an important part in the pathogenesis of immune thrombocytopenic purpura. The coating of platelets with immunoglobulin results in their removal in the spleen and liver, presumably by receptors for the Fc fragment of IgG (Fcγ).1 , 2 Prolongation of Fcγ-receptor-mediated clearance of opsonized red cells after splenectomy1 , 3 and infusions of high doses of intravenous gamma globulin,4 , 5 in conjunction with favorable clinical responses to these therapies, support this hypothesis. Some patients, however, respond to neither of these treatments nor to other, less specific forms of immunosuppression, such . . .