Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation

作者：Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo J. Vegas, Delai Chen, Kaitlin M. Bratlie, Tram T. Dang, Roger L. York, Jennifer Hollister‐Lock, Gordon C. Weir, Daniel G. Anderson · 发表于：Advanced Healthcare Materials · 年份：2012 · DOI：10.1002/adhm.201200341 · 被引用次数：164 · 研究领域：Pancreatic function and diabetes、Electrohydrodynamics and Fluid Dynamics、Cannabis and Cannabinoid Research

Islets microencapsulation holds great promise to treat type 1 diabetes. Currently used alginate microcapsules often have islets protruding outside capsules, leading to inadequate immuno-protection. A novel design of microcapsules with core-shell structures using a two-fluid co-axial electro-jetting is reported. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.