Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon

作者：Aroor R. Rao, A. Robert Kagan, Paul Y. M. Chan, Harvey A. Gilbert, Herman Nussbaum, Brace L. Hintz · 发表于：Cancer · 年份：1981 · DOI：10.1002/1097-0142(19810915)48:6<1492::aid-cncr2820480636>3.0.co;2-k · 被引用次数：212 · 研究领域：Colorectal Cancer Surgical Treatments、Colorectal and Anal Carcinomas、Gastric Cancer Management and Outcomes

Two-hundred-four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy-eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurrence alone, 28% (22/78) with regional recurrence, 15% (12/78) with concomitant local recurrence and distant metastasis, and 17% (13/78) with distant metastasis alone. The degree of tumor anaplasia and depth of tumor penetration into the bowel wall influenced the rate of local recurrence. Through five years local recurrence without clinical evidence of distant metastasis was the most common cause of death. Need for adjuvant radiation therapy is discussed.