PRODUCTION OF EXPERIMENTAL HYPERTENSION BY ALDOSTERONE

作者：F. Gross, Prosper Loustalot, Rhonda L. Meier · 发表于：European Journal of Endocrinology · 年份：1957 · DOI：10.1530/acta.0.0260417 · 被引用次数：53 · 研究领域：Hormonal Regulation and Hypertension、Eicosanoids and Hypertension Pharmacology

In a previous experiment it was found that daily doses of 0.04 mg. of d-aldosterone administered to rats for 4 weeks did not produce any hypertension while daily doses of 1 mg. of cortexone-acetate (DOCA) which have a comparable sodium retaining activity produced a typical increase in blood pressure (Gross, Loustalot & Meier, 1955). On the other hand Gornall et al. (1957) reported that very small doses of aldosterone (0.5–1.0 μg. daily or every two days) produced hypertension in rats within six months of treatment independently of the salt intake (Gornall et al., 1957; Kumar et al., 1956; Kumar et al., 1957). These findings, however, have not been confirmed by Gaunt et al. (1957). Since larger amounts of aldosterone have recently become available, it has been possible to undertake further overdosage experiments in order to evaluate the possible hypertensive activity of aldosterone and to compare it with that of cortexone.