Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae)

作者：Jonel P. Saludes, Mary J. Garson, Scott Gary Franzblau, Alicia M. Aguinaldo · 发表于：Phytotherapy Research · 年份：2002 · DOI：10.1002/ptr.1003 · 被引用次数：141 · 研究领域：Morinda citrifolia extract uses、Bioactive Compounds and Antitumor Agents、Natural product bioactivities and synthesis

A crude ethanol extract and hexane fraction from Morinda citrifolia Linn. (Rubiaceae) show antitubercular activity. The major constituents of the hexane fraction are E-phytol, cycloartenol, stigmasterol, beta-sitosterol, campesta-5,7,22-trien-3beta-ol and the ketosteroids stigmasta-4-en-3-one and stigmasta-4-22-dien-3-one. E-Phytol, a mixture of the two ketosteroids, and the epidioxysterol derived from campesta-5,7,22-trien-3beta-ol all show pronounced antitubercular activity.