THE CIRCULATION IN FOREARM SKIN AND MUSCLE DURING ADRENALINE INFUSIONS

作者：SL Skinner, R. F. Whelan · 发表于：Immunology and Cell Biology · 年份：1962 · DOI：10.1038/icb.1962.19 · 被引用次数：19 · 研究领域：Hemodynamic Monitoring and Therapy、Cardiovascular and exercise physiology、Cardiovascular Syncope and Autonomic Disorders

SUMMARY The effect of intravenous and intra‐arterial adrenaline Infusions on the circulation in skin and muscle of the human forearm has been followed by the technique of superficial and deep venous blood oximetry. Forearm blood flow was measured by venous occlusion plethysmography. The initial transient increase in forearm blood flow seen on both intravenous and intra‐arterial infusion of adrenaline was associated with an abrupt increase in deep blood oxygen saturation indicating an increase in muscle blood flow and the subsequent sustained increase in forearm blood flow during intravenous infusion was also accompanied by an increased muscle blood oxygen saturation. Similar increases were seen during intra‐arterial infusion of 0·05 and 0·1 μg./min., a dose of 0·2 μg./min. intra‐arterially also increased the muscle blood flow although the total forearm flow was reduced, while larger doses (0·5 μg./min.) caused a fall in both muscle flow and total forearm flow. The “after‐dilatation”, only seen following intra‐arterial infusions, was more marked with the larger doses and is attributed to the wearing off of a transient constrictor effect on the muscle vessels. Superficial blood oxygen saturation was reduced by most doses of adrenaline indicating a decrease in skin blood flow. The findings indicate that the dilator action of adrenaline on muscle vessels has a longer duration than the constrictor action.