Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

作者：Olivier Pourquié, Monique Coltey, M A Teillet, Charles P. Ordahl, Nicole M. Le Douarin · 发表于：Proceedings of the National Academy of Sciences · 年份：1993 · DOI：10.1073/pnas.90.11.5242 · 被引用次数：312 · 研究领域：Developmental Biology and Gene Regulation、Connective tissue disorders research、Congenital heart defects research

We have examined the effect of implantation of a supernumerary notochord or floor plate on dorsoventral somitic organization. We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives--i.e., axial muscles and dermis--thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.