Microfluidic Generation of Multifunctional Quantum Dot Barcode Particles

作者：Yuanjin Zhao, Ho Cheung Shum, Haosheng Chen, Laura Adams, Zhongze Gu, David A. Weitz · 发表于：Journal of the American Chemical Society · 年份：2011 · DOI：10.1021/ja200729w · 被引用次数：263 · 研究领域：Innovative Microfluidic and Catalytic Techniques Innovation、Pickering emulsions and particle stabilization、Electrowetting and Microfluidic Technologies

We develop a new strategy to prepare quantum dot (QD) barcode particles by polymerizing double-emulsion droplets prepared in capillary microfluidic devices. The resultant barcode particles are composed of stable QD-tagged core particles surrounded by hydrogel shells. These particles exhibit uniform spectral characteristics and excellent coding capability, as confirmed by photoluminescence analyses. By using double-emulsion droplets with two inner droplets of distinct phases as templates, we have also fabricated anisotropic magnetic barcode particles with two separate cores or with a Janus core. These particles enable optical encoding and magnetic separation, thus making them excellent functional barcode particles in biomedical applications.