Molecular and functional aspects of PECAM-1/CD31

作者：Horace M. DeLisser, Peter J. Newman, Steven Μ. Albelda · 发表于：Immunology Today · 年份：1994 · DOI：10.1016/0167-5699(94)90195-3 · 被引用次数：317 · 研究领域：Cell Adhesion Molecules Research、Platelet Disorders and Treatments、Proteoglycans and glycosaminoglycans research

Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment. This makes it uniquely positioned to mediate multiple and important cell-cell interactions involving platelets, leukocytes and endothelial cells. Thus, PECAM-1 may represent a potential target for new therapeutic agents directed at a variety of pathological states.