Long-lasting sonographic and histopathological findings in cured clonorchiasis of rabbits

作者：Dongil Choi, Jae Hoon Lim, Seung Kwon Kim, Eung Yeop Kim, Mejeong Lee, Sung‐Tae Hong · 发表于：Korean Journal of Parasitology · 年份：1999 · DOI：10.3347/kjp.1999.37.2.77 · 被引用次数：11 · 研究领域：Parasites and Host Interactions、Parasite Biology and Host Interactions、Helminth infection and control

To ascertain residual sonographic and histopathological findings of clonorchiasis after treatment, the present study evaluated sonographic findings in rabbits which were infected with 500 metacercariae of C. sinensis every 6 months for 18 months after treatment with praziquantel. The sonographic findings were analyzed in terms of intrahepatic bile duct dilatation and periductal echogenicity, and histopathological findings were observed after the last sonographic examination. Compared with the sonographic findings before treatment, dilatation of the intrahepatic bile ducts became mild to some degree in four of the seven cases and increased periductal echogenicity resolved in four of them. The histopathological specimens after 18 months showed that periductal inflammation has almost resolved but moderate dilatation of the intrahepatic ducts and mucosal hyperplasia persisted. The periductal fibrosis minimally resolved. The long-lasting sonographic findings in cured clonorchiasis make sonography less specific.