Regulation of Axon Formation by Clonal Lines of a Neural Tumor

作者：Nicholas W. Seeds, Alfred G. Gilman, Takehiko Amano, Marshall W. Nirenberg · 发表于：Proceedings of the National Academy of Sciences · 年份：1970 · DOI：10.1073/pnas.66.1.160 · 被引用次数：480 · 研究领域：Neuroblastoma Research and Treatments、Microtubule and mitosis dynamics、Skin and Cellular Biology Research

Clonal lines of neuroblastoma cells were found to extend or retract axons depending upon the concentration of serum. Neurite extension was not inhibited by cycloheximide but was sensitive to colchicine or vinblastine, suggesting that neurite formation is dependent upon the assembly of microtubules or neurofilaments from preformed protein subunits.