Emergence of KPC-2-Producing Pseudomonas aeruginosa Sequence Type 463 Isolates in Hangzhou, China

作者：Yanyan Hu, Danxia Gu, Jiachang Cai, Hongwei Zhou, Rong Zhang · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2015 · DOI：10.1128/aac.04903-14 · 被引用次数：38 · 研究领域：Antibiotic Resistance in Bacteria、Bacterial biofilms and quorum sensing、Pharmaceutical and Antibiotic Environmental Impacts

Thirty-nine Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa isolates, all exhibiting high-level resistance to carbapenems and other β-lactam antibiotics, were isolated in Hangzhou, China. Molecular epidemiology analysis indicated the presence of two dominant clones, namely, clones A and B, both of which belong to sequence type 463 (ST463). A genetic environment analysis demonstrated that both clones harbor an ISKpn8 transposase, bla(KPC-2), and an ISKpn6-like transposase. These findings depict the features of clonal expansion and transmission of KPC-2-producing P. aeruginosa strains in Hangzhou, China.