Relationship between Cigarette Smoking and Novel Risk Factors for Cardiovascular Disease in the United States

作者：Lydia Bazzano, Jiang He, Paul Muntner, Suma X. Vupputuri, Paul Kieran Whelton · 发表于：Annals of Internal Medicine · 年份：2003 · DOI：10.7326/0003-4819-138-11-200306030-00010 · 被引用次数：410 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Alcohol Consumption and Health Effects、Folate and B Vitamins Research

BACKGROUND: Few studies have examined the relationship between cigarette smoking and novel risk factors for cardiovascular disease in a general population or have included a biochemical marker of current smoking. OBJECTIVE: To examine the relationship between cigarette smoking and serum C-reactive protein, fibrinogen, and homocysteine levels. DESIGN: Cross-sectional study. SETTING: The U.S. general population. PATIENTS: 4187 current smokers, 4791 former smokers, and 8375 never-smokers 18 years of age or older who participated in the Third National Health and Nutrition Examination Survey conducted between 1988 and 1994. MEASUREMENTS: Serum C-reactive protein levels were categorized as detectable (2.2 to 9.9 mg/L) or clinically elevated (> or =10 mg/L), and fibrinogen and homocysteine levels were defined as elevated if in the 85th percentile or greater (11.1 micromol/L and 12.7 mmol/L, respectively). RESULTS: After adjustment for traditional cardiovascular disease risk factors, cigarette smoking was related to elevated levels of C-reactive protein, fibrinogen, and homocysteine. Compared with never smoking cigarettes, self-reported current cigarette smoking was associated with a C-reactive protein level in the detectable (odds ratio, 1.66 [95% CI, 1.40 to 1.97]; P < 0.001) or clinically elevated (odds ratio, 1.98 [CI, 1.57 to 2.51]; P < 0.001) ranges, with elevated levels of fibrinogen (odds ratio, 2.15 [CI, 1.65 to 2.80]; P < 0.001) and homocysteine (odds ratio, 2.10 [CI, 1.62 ...