Relationship of depth of brain lesions to consciousness and outcome after closed head injury

作者：Harvey S. Levin, David J. Williams, Marsha J. Crofford, Walter M. High, Howard M. Eisenberg, Eugenio G. Amparo, Faustino C. Guinto, Zvi Kalisky, Stanley F. Handel, Arnold M. Goldman · 发表于：Journal of neurosurgery · 年份：1988 · DOI：10.3171/jns.1988.69.6.0861 · 被引用次数：118 · 研究领域：Traumatic Brain Injury and Neurovascular Disturbances、Traumatic Brain Injury Research、Automotive and Human Injury Biomechanics

Magnetic resonance (MR) imaging was performed in 94 patients who sustained closed head injury of varying severity. Results of MR studies obtained after the intensive care phase of treatment disclosed that intracranial lesions were present in about 88% of the patients. Consistent with the centripetal model of progressive brain injury proposed in 1974 by Ommaya and Gennarelli, the depth of brain lesion was positively related to the degree and duration of impaired consciousness. Further analysis indicated that the relationship between depth of brain lesion and impaired consciousness could not be attributed to secondary effects of raised intracranial pressure or to the size of intracranial lesion(s).