The dopaminergic innervation of the ventral striatum in the rat: A light‐ and electron‐microscopical study with antibodies against dopamine

作者：Pieter Voorn, Barbara Jorritsma‐Byham, Corry Van Dijk, Ruud M. Buijs · 发表于：The Journal of Comparative Neurology · 年份：1986 · DOI：10.1002/cne.902510106 · 被引用次数：319 · 研究领域：Neurotransmitter Receptor Influence on Behavior、Neuroscience and Neuropharmacology Research、Zebrafish Biomedical Research Applications

Dopamine (DA) in the dorsal and ventral striatum is associated with different aspects of locomotor activity control. The ventral striatum may form an interface between the limbic system and the extrapyramidal motor system. The distribution of dopaminergic fibers in this interface position was studied in detail with a method applying antibodies against DA. Furthermore, the ultrastructural morphology of the DA fibers was examined by means of immuno-electron microscopy. The results show that DA immunoreactivity is distributed over the ventral striatum in a highly compartmentalized fashion. In the dorsal striatum few compartments were found. The DA fibers in the ventral striatum establish mainly symmetric synaptic contacts, preferably with dendritic shafts and spines. The results are discussed in relation to previous data concerning the light and electron-microscopic identification of catecholaminergic fibers in the ventral and dorsal striatum.