Physician-Directed Patient Self-Management of Left Atrial Pressure in Advanced Chronic Heart Failure

作者：Jay Ritzema, Richard William Troughton, Iain Melton, Ian Crozier, Robert Neil Doughty, Henry Krum, Anthony S. Walton, Philip B. Adamson, Saibal Kar, Prediman Krishan Shah, Mark Richards, Neal L Eigler, James S. Whiting, Garrie J. Haas, James Thomas Heywood, CHRISTOPHER M. A. FRAMPTON, William T. Abraham · 发表于：Circulation · 年份：2010 · 被引用次数：319 · 研究领域：Cardiovascular Function and Risk Factors、Heart Failure Treatment and Management、Atrial Fibrillation Management and Outcomes

BACKGROUND: Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS: Forty patients with reduced or preserved left ventricular ejection fraction and a history of New York Heart Association class III or IV heart failure and acute decompensation were implanted with an investigational left atrial pressure monitor, and readings were acquired twice daily. For the first 3 months, patients and clinicians were blinded as to these readings, and treatment continued per usual clinical assessment. Thereafter, left atrial pressure and individualized therapy instructions guided by these pressures were disclosed to the patient. Event-free survival was determined over a median follow-up of 25 months (range 3 to 38 months). Survival without decompensation was 61% at 3 years, and events tended to be less frequent after the first 3 months (hazard ratio 0.16 [95% confidence interval 0.04 to 0.68], P=0.012). Mean daily left atrial pressure fell from 17.6 mm Hg (95% confidence interval 15.8 to 19.4 mm Hg) in the first 3 months to 14.8 mm Hg (95% confidence interval 13.0 to 16.6 mm Hg; P=0.003) during pressure-guided therapy. The frequency of elevated readings (>25 mm Hg) was reduced by 67% (P<0.001). There were improvements in New York Heart Association class (-0.7+/-0.8,...