Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 -/- Mice

作者：Dow-Rhoon Koh, Wai‐Ping Fung‐Leung, Alexandra Ho, Dawn M. Gray, Hans Acha‐Orbea, T W Mak · 发表于：Science · 年份：1992 · DOI：10.1126/science.256.5060.1210 · 被引用次数：357 · 研究领域：Immunotherapy and Immune Responses、T-cell and B-cell Immunology、RNA Interference and Gene Delivery

Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)-susceptible PL/JH-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.