Helicobacter pylori persistence: biology and disease

作者：Martin J. Blaser, John C. Atherton · 发表于：Journal of Clinical Investigation · 年份：2004 · DOI：10.1172/jci20925 · 被引用次数：935 · 研究领域：Helicobacter pylori-related gastroenterology studies、Eosinophilic Esophagitis、Microbial Metabolites in Food Biotechnology

Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.