Enantioselective α-Amination of 1,3-Dicarbonyl Compounds Using Squaramide Derivatives as Hydrogen Bonding Catalysts

作者：Hideyuki Konishi, Tin Yiu Lam, Jeremiah P. Malerich, Viresh H. Rawal · 发表于：Organic Letters · 年份：2010 · DOI：10.1021/ol1005104 · 被引用次数：247 · 研究领域：Asymmetric Synthesis and Catalysis、Synthesis and Catalytic Reactions、Chemical Synthesis and Analysis

Catalytic enantioselective alpha-hydrazination of 1,3-dicarbonyl compounds with azodicarboxylates was investigated in the presence of our newly developed hydrogen bonding catalyst, squaramide 3j. High yields and high enantioselectivities were achieved with low catalyst loading under mild conditions.