Wounding and Its Role in RSV-Mediated Tumor Formation

作者：David S. Dolberg, Robert E. Hollingsworth, Mark Hertle, Mina J. Bissell · 发表于：Science · 年份：1985 · DOI：10.1126/science.2996144 · 被引用次数：230 · 研究领域：Virus-based gene therapy research、Animal Virus Infections Studies、Viral Infectious Diseases and Gene Expression in Insects

Tumors induced in chickens by Rous sarcoma virus remain localized at the site of injection even though the animals become viremic. Tumors have now been shown to be inducible at other sites if a wound is inflicted or if the tissue is injured by administration of tumor promoters. These findings indicate that local wounding plays a role in the spread of tumorigenicity of Rous sarcoma virus.