Effects of Oral Contraceptives on Blood Coagulation. A Review

作者：Fritz Karl Beller, Christa Ebert · 发表于：Obstetrical & Gynecological Survey · 年份：1985 · DOI：10.1097/00006254-198507000-00003 · 被引用次数：82 · 研究领域：Reproductive Health and Contraception、Hormonal and reproductive studies、Blood Coagulation and Thrombosis Mechanisms

A review of the data from studies of oral contraceptives on coagulation and the fibrinolytic enzyme systems reveal an increase of a variety of coagulation factors. This is dose dependent and related to estrogens and appreciable above a dose of 0.5 micrograms of ethynylestradiol. Smaller amounts are less effective or not at all active. The mechanism of this increase is unknown. The pathophysiological significance is not yet clear. There is no available data that associate the increase of coagulation factors with disseminated intravascular coagulation. Conclusive evidence that low dose progesterone has any effect on the coagulation system is lacking.