Vaccination with Recombinant Herpes Simplex Virus Glycoproteins: Protection Against Initial and Recurrent Genital Herpes

作者：Lawrence Raymond Stanberry, David I. Bernstein, Rae Lyn Burke, Carol A. Pachl, M. G. Myers · 发表于：The Journal of Infectious Diseases · 年份：1987 · DOI：10.1093/infdis/155.5.914 · 被引用次数：198 · 研究领域：Herpesvirus Infections and Treatments、Hepatitis B Virus Studies、Cytomegalovirus and herpesvirus research

The natural history of initial and subsequent recurrent herpes simplex virus (HSV) genital infection was studied in guinea pigs immunized with HSV glycoprotein vaccines before vaginal challenge with HSV-2. The vaccines used included HSV-1 glycoprotein B and HSV-1 glycoprotein D, both prepared by recombinant DNA techniques, and mixtures of HSV-1 or HSV-2 glycoproteins, prepared from infected cell monolayers by lectin chromatography. Immunizing guinea pigs with subunit HSV glycoprotein vaccines favorably altered the clinical and virological course of initial infection and substantially reduced the incidence, frequency, and duration of recurrent herpetic infections. The extent of protection was influenced by the nature of the glycoprotein vaccine, the immunizing dose, and the co-administration of adjuvant.