The Insulin-Like Growth Factor-I Receptor

作者：Pierre De Meyts, Brenda J. Wallach, Claus T. Christoffersen, Birgitte Ursø, Karen Gr oslash nskov, Lori-Jo Latus, Fumiatsu Yakushiji, Mapoko M. Ilondo, Ronald M. Shymko · 发表于：Hormone Research · 年份：2008 · DOI：10.1159/000184188 · 被引用次数：324 · 研究领域：Metabolism, Diabetes, and Cancer、Growth Hormone and Insulin-like Growth Factors、Pancreatic function and diabetes

The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our recently proposed novel binding mechanism whereby the bivalent ligand bridges the two receptor alpha-subunits alternatively at opposite sites in a symmetrical receptor structure. The bivalent binding mechanism also explains bell-shaped bioactivity curves. The possible role of different binding modes versus differences in downstream signaling by insulin and IGF-I in producing specific mitogenic or metabolic responses is discussed.