lac Repressor blocks transcribing RNA polymerase and terminates transcription.

作者：Ulrich Deuschle, Reiner Gentz, Hermann Bujard · 发表于：Proceedings of the National Academy of Sciences · 年份：1986 · DOI：10.1073/pnas.83.12.4134 · 被引用次数：114 · 研究领域：Galectins and Cancer Biology、ATP Synthase and ATPases Research、Nanoparticle-Based Drug Delivery

Operator sequences are essential elements in many negatively controlled operons. By binding repressors, they prevent the formation of active complexes between RNA polymerase and promoters. Here we show that the Escherichia coli lac operator-repressor complex also efficiently interrupts ongoing transcription. This observation suggests a mechanism of action for operators located distal to promoter sequences.