A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis

作者：Jian Xu, Magnus Bjursell, Jason Himrod, Su Deng, Lynn K. Carmichael, Herbert C. Chiang, Lora V. Hooper, Jeffrey I. Gordon · 发表于：Science · 年份：2003 · DOI：10.1126/science.1080029 · 被引用次数：1364 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Microbial Metabolites in Food Biotechnology

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobe Bacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.