beta-endorphin is a potent analgesic agent.

作者：Horace H. Loh, Leon F. Tseng, E.T. Wei, C H Li · 发表于：Proceedings of the National Academy of Sciences · 年份：1976 · DOI：10.1073/pnas.73.8.2895 · 被引用次数：475 · 研究领域：Neuropeptides and Animal Physiology、Receptor Mechanisms and Signaling、Pain Mechanisms and Treatments

beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.