Theoretical and experimental study of electroporation of red blood cells using MEMS technology

作者：Peigang Deng, Guangyao Yin, Tongyi Zhang, Denis Chang, Yi-Kuen Lee · 年份：2010 · DOI：10.1109/nems.2010.5592472 · 被引用次数：2 · 研究领域：Microbial Inactivation Methods、Microfluidic and Bio-sensing Technologies、Nanomaterials and Printing Technologies

A theoretical and experimental study of electroporation (EP) of red blood cells (RBCs) was presented in this paper. With additional strain energy, an energy-based model of an electropore induced on a RBC's membrane at different electric fields was proposed to predict the critical EP electric field strength. In addition, EP experiments with red blood cells at single-cell level was carried out on a micro EP chip. The measured critical EP electric field strengths are in agreement with the numerical predictions.