hBD‐1: a novel β‐defensin from human plasma

作者：Klaus W. Bensch, Manfred Raida, Hans‐Jürgen Mägert, Peter Schulz‐Knappe, Wolf‐Georg Forssmann · 发表于：FEBS Letters · 年份：1995 · DOI：10.1016/0014-5793(95)00687-5 · 被引用次数：545 · 研究领域：Antimicrobial Peptides and Activities、Polydiacetylene-based materials and applications、Biochemical and Structural Characterization

We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide. hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.