Imaging β-amyloid burden in aging and dementia

作者：Christopher C. Rowe, Sally Ng, Uwe Ackermann, S. Gong, Kerryn Elizabeth Pike, Greg R. Savage, Tiffany Cowie, Katherine L. Dickinson, Paul T. Maruff, D Darby, Clare L. Smith, Mark Woodward, John R. Merory, Henri Tochon‐Danguy, Graeme Joseph O'Keefe, William E. Klunk, Chester A. Mathis, Julie C. Price, Colin Louis Masters, Victor L. Villemagne · 发表于：Neurology · 年份：2007 · DOI：10.1212/01.wnl.0000261919.22630.ea · 被引用次数：1114 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Schizophrenia research and treatment

OBJECTIVE: To compare brain beta-amyloid (Abeta) burden measured with [(11)C]Pittsburgh Compound B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias. METHODS: Thirty-three subjects with dementia (17 AD, 10 dementia with Lewy bodies [DLB], 6 frontotemporal dementia [FTD]), 9 subjects with mild cognitive impairment (MCI), and 27 age-matched healthy control subjects (HCs) were studied. Abeta burden was quantified using PIB distribution volume ratio. RESULTS: Cortical PIB binding was markedly elevated in every AD subject regardless of disease severity, generally lower and more variable in DLB, and absent in FTD, whereas subjects with MCI presented either an "AD-like" (60%) or normal pattern. Binding was greatest in the precuneus/posterior cingulate, frontal cortex, and caudate nuclei, followed by lateral temporal and parietal cortex. Six HCs (22%) showed cortical uptake despite normal neuropsychological scores. PIB binding did not correlate with dementia severity in AD or DLB but was higher in subjects with an APOE-epsilon4 allele. In DLB, binding correlated inversely with the interval from onset of cognitive impairment to diagnosis. CONCLUSIONS: Pittsburgh Compound B PET findings match histopathologic reports of beta-amyloid (Abeta) distribution in aging and dementia. Noninvasive longitudinal studies to better understand the role of amyloid deposition in the course of neurodegeneration and to determine if Abeta deposition in nondemented subjects is preclinic...