Disseminated Intravascular Coagulation in the Newborn

作者：William G. Woods · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：1979 · DOI：10.1001/archpedi.1979.02130010050008 · 被引用次数：18 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Autopsy Techniques and Outcomes、Maternal and fetal healthcare

We have reviewed 53 cases of disseminated intravascular coagulation (DIC) in the newborn, including 29 cases that were confirmed at autopsy. Factors predisposing to DIC included maternal complications (60%), low Apgar scores (30%), hyaline membrane disease (62%), and sepsis (26%). Diagnostic criteria common to autopsy-proved cases included presence of fibrin degradation products, low factor V activity, a prolonged prothrombin time, and a prolonged partial thromboplastin time and/or thrombocytopenia. There appeared to be no difference in coagulation response or in mortality among patients treated with different therapeutic regimens. Survivors were older gestationally, had higher birth weights, and higher Apgar scores.