Search for Enteric Microbial Pathogens in Patients with Ulcerative Colitis

作者：W.J. Brown, Mark James Hudson, Sheila Patrick, S.C.W. Matthews, M. J. Hill, Alasdair Edward Gent, R H Grace, M.D. Hellier, E.T. Swarbrick · 发表于：Digestion · 年份：2009 · DOI：10.1159/000200985 · 被引用次数：26 · 研究领域：Clostridium difficile and Clostridium perfringens research、Microscopic Colitis、Inflammatory Bowel Disease

Microbial pathogens were sought in faeces of patients with active ulcerative colitis and again after 3 months treatment. 64 patients were examined during their first episode of ulcerative colitis and 30 with relapse of chronic disease. At presentation, bacterial pathogens were not found; 1 patient had cryptosporidiosis. In 10 patients treatment appeared to result in some loss of colonisation resistance as evidenced by colonisation with beta-haemolytic streptococci, Staphylococcus aureus, candida and Clostridium difficile. Unidentified cytotoxic activity was present in the faeces of 4 patients at presentation and 2 patients during or after treatment. We conclude that enteric infection is an uncommon finding in patients with active ulcerative colitis.