Induction of T-Cell Differentiation In Vitro by Thymin, a Purified Polypeptide Hormone of the Thymus

作者：Ross S. Basch, Gideon Goldstein · 发表于：Proceedings of the National Academy of Sciences · 年份：1974 · DOI：10.1073/pnas.71.4.1474 · 被引用次数：137 · 研究领域：Glycosylation and Glycoproteins Research、Transgenic Plants and Applications、Myasthenia Gravis and Thymoma

Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.