The neural substrates of response inhibition to negative information across explicit and implicit tasks in GAD patients: electrophysiological evidence from an ERP study

作者：Fengqiong Yu, Chunyan Zhu, Lei Zhang, Xingui Chen, Dan Li, Long Zhang, Rong Ye, Yi Dong, Yuejia Luo, Xinlong Hu, Kai Wang · 发表于：Frontiers in Psychology · 年份：2015 · DOI：10.3389/fpsyg.2015.00275 · 被引用次数：15 · 研究领域：Neural and Behavioral Psychology Studies、Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes、Memory and Neural Mechanisms

BACKGROUND: It has been established that the inability to inhibit a response to negative stimuli is the genesis of anxiety. However, the neural substrates of response inhibition to sad faces across explicit and implicit tasks in general anxiety disorder (GAD) patients remain unclear. METHODS: Electrophysiological data were recorded when subjects performed two modified emotional go/no-go tasks in which neutral and sad faces were presented: one task was explicit (emotion categorization), and the other task was implicit (gender categorization). RESULTS: In the explicit task, electrophysiological evidence showed decreased amplitudes of no-go/go difference waves at the N2 interval in the GAD group compared to the control group. However, in the implicit task, the amplitudes of no-go/go difference waves at the N2 interval showed a reversed trend. Source localization analysis on no-go/N2 components revealed a decreased current source density (CSD) in the right dorsal lateral prefrontal cortex in GAD individuals relative to controls. In the implicit task, the left superior temporal gyrus and the left inferior parietal lobe showed enhanced activation in GAD individuals and may compensate for the dysfunction of the right dorsal lateral prefrontal cortex. CONCLUSION: These findings indicated that the processing of response inhibition to socially sad faces in GAD individuals was interrupted in the explicit task. However, this processing was preserved in the implicit task. The neural subst...