Epilepsy, Atherosclerosis, Myocardial Infarction, and Carbamazepine

作者：Jean‐Pierre de Chadarévian, Agustín Legido, Daniel K. Miles, Christos D. Katsetos · 发表于：Journal of Child Neurology · 年份：2003 · DOI：10.1177/08830738030180021301 · 被引用次数：27 · 研究领域：Pharmacological Effects and Toxicity Studies、Epilepsy research and treatment、Neurological and metabolic disorders

Epileptic patients receiving medications such as phenytoin or phenobarbital have been noted to have an exceedingly low incidence of myocardial infarction, but children treated with carbamazepine have shown alteration of their serum lipid profile that could predispose them to atherosclerosis. This report seems to corroborate this point and describes the findings in an 11-year-old boy who died following a major seizure, rhabdomyolysis, and renal failure. The autopsy demonstrated that he had marked coronary atherosclerosis and myocardial infarction. The child had been treated with carbamazepine for more than 10 years.